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Nucleic Acids Research, 1981, Vol. 9, No. 1 161-168
© 1981

ENZYMOLOGY

Studies on the inhibition of highly purified calf thymus 8S and 7.3S DNA polymeiase {alpha} by aphidicolin

Andrew M. Holmes*

Biochemistry Department, Strathclyde University The Todd Centre, 31 Taylor Street, Glasgow G4 ONR, UK

Received October 14, 1980.

On activated DNA aphidicolin competitively inhibits the incorporation of dCMP by both calf thymus DNA polymerase {alpha} A2 and C enzymes and inhibits the incorporation of the other three deoxynucleoside monophosphates apparently non-competitively. However, aphidicolin does not inhibit the incorporation of dAMP into poly(dT).oligo(A)10 nor does it inhibit the incorporation of dGMP into poly(dC).oligo(dG)10, but, it does competitively inhibit the incorporation of dTMP into poly(dA).oligo-(dT)10.

*Biochemistry Department, Uniformed Services University of the Health Sciences, School of Medicine, 4301 Jones Bridge Road, Bethesda, Maryland 20014, USA


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