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Nucleic Acids Research, 1981, Vol. 9, No. 1 169-181
© 1981

MOLECULAR BIOLOGY

Sequence relationships between single repeat units of highly reiterated African Green monkey DNA

Ronald E. Thayer, Maxine F. Singer and Thomas F. McCutchan

Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health Bethesda, MD 20205, USA

Received October 10, 1980. Individual monomer and dimer units of the highly repeated {alpha}-component DNA of African Green monkeys were isolated and amplified by molecular cloning in pBR322. The purified sequences were characterized by digestion with restriction endonucleases and by primary nucleotlde sequence analysis. Comparison of the cloned units with the 172 base pair long sequence representing the most abundant nucleotide at each position in the set of sequences comprising {alpha}-component allows the following conclusions. The set of sequences comprising {alpha}-component is made up of a very large number of related but slightly divergent sequences. Two neighboring repeats of the monomer unit are not necessarily more similar to one another than are randomly isolated monomers.

One of the cloned segments is an almost perfect inverted repeat of a portion of the {alpha}-component monomer. Although cloning artefacts cannot now be excluded, the possibility that such inversions occur in the monkey genome is of interest.


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