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Nucleic Acids Research, 1981, Vol. 9, No. 17 4213-4224
© 1981

MOLECULAR BIOLOGY

Highly variable regions of DNA flank the human {alpha} globin genes

D.R. Higgs, S.E.Y. Goodbourn, J.S. Wainscoat, J.B. Clegg and D.J. Weatherall

M.R.C. Molecular Haematology Unit, Nuffield Department of Clinical Medicine, John Radcliffe Hospital Oxford 0X3 9DU, UK

Received July 23, 1981. A series of restriction fragment length polymorphisms which are due to DNA rearrangements have been identified within two highly variable regions flanking the human {alpha} globin genes. The existence of such highly polymorphic areas provides a large number of individual genetic markers for the {alpha} globin gene cluster on chromosome 16. If, as seems likely, such regions occur frequently throughout the human genome they should be of considerable value in the antenatal diagnosis of genetic disease.


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