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Nucleic Acids Research, 1981, Vol. 9, No. 18 4745-4753
© 1981

MOLECULAR BIOLOGY

Homologous 3'-terminal regions of mRNAs for surface antigens of different antigenic variants of Trypanosoma brucei

Hemanta K. Majumder, John C. Boothroyd* and Hans Weber

Institut für Molekularbiologie I, Universität Zürich 8093 Zürich, Switzerland *Wellcome Research Laboratories, Department of Immunochemistry, Langley Court Beckenham, Kent BR3 3BS, UK

Received June 16, 1981. Sequences corresponding to the complete 3'-terminal regions of the messenger RNAs for three different Variant Surface Glycoproteins of Trypanosoma brucei were determined on complementary DNA inserts cloned in recombinant plasmids. The three sequences show 80-130 base pair long segments of strong (70-80%) homology at the 3' ends, whereas the regions upstream from the last 130-140 base pairs contain no significant homology. The signal AAUAAA, present near the 3' ends of almost all known polyadenylated mRNAs of eukaryotes, does not occur in the 3'-terminal sequences of these three variants.


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