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Nucleic Acids Research, 1981, Vol. 9, No. 21 5737-5746
© 1981

MOLECULAR BIOLOGY

Histone gene number in relation to C-value in amphibians

Vaughan A. Hilder, R. Nigel Livesey, Philip C. Turner and Marcela T. Vlad

Received August 18, 1981. We have compared the number of copies of sequences complementary to a cloned Xenopus histone H4 coding sequence in the genomes of Xenopus, Triturus and Ambystoma, amphibian species with widely different C-values (3, 23 and 38pg DNA/haploid genome respectively). Quantitative autoradiography indicates that H4 sequences constitute a greater proportion of the genome the larger that genome is. Measurement of the absolute copy-number by reassociation kinetic analysis indicated 47±10, 636+21 and 2685±349 copies per haplold genome each in Xenopus, Triturus and Ambystoma respectively. Whilst this confirms a trend of increasing copy-number with increasing C-value, the two are not directly proportional and some other factors must contribute to determining the number of copies of these genes.


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