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Nucleic Acids Research, 1981, Vol. 9, No. 23 6571-6590
© 1981

MOLECULAR BIOLOGY

Nudeotide sequence of the transforming early region Elb of adenovirus type 12 DNA: structure and gene organization, and comparison with those of adenovirus type 5 DNA

Takao Kimura1, Yukiharu Sawada1, Morikazu Shinawawa2, Yasuaki Shimizu1, Kazuko Shiroki3, Hiroto Shimojo3, Hiroyuki Sugisaki4, Mituru Takanami4, Yoshiko Uemizu1 and Kei Fujinaga1,5

1Cancer Research Inst., Sapporo Medical Coll. Sapporo 060 2Dep. Veterinary Public Health, Obihiro Univ. Agriculture and Veterinary Medicine Obihiro 3Inst. Medical Science, Univ. Tokyo, Minato-ku, Tokyo 108 4Inst. Chemical Research, Kyoto Univ. Uji, Kyoto 611, Japan

5To ehom reprint requests should be addressed

Received September 14, 1981. The nudeotide sequence of the entire transforming early region Elb of the highly oncogenic adenovirus type 12 (Adl2) DNA has been determined. The total sequence (3860 base pairs) encompasses the entire transforming early region El of Adl2 DNA. From the sequence for the Elb region of Adl2, and the transcription map of the Elb region (1, 2, 3, and this paper) the structure and gene organization of the early region Elb of Adl2 DNA were analyzed and compared with those of the Elb region in the non-oncogenic Ad5 DNA (4, 5). Most of the sequences in the Elb region of Adl2 was highly homologous to that of Ad5. It is predicted that the Adl2 region Elb codes for polypeptides of 53.9, 19.1, and 8.9 kd. This situation is identical with that of the Ad5 region Elb which codes for polypeptides of 54.9, 20.6, and 8.3 kd. The function of these predicted polypeptides encoded by the Elb regions in cell transformation is discussed.


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