Nucleic Acids Research, 1981, Vol. 9, No. 24 6647-6668
© 1981
SURVEYS AND SUMMARIES |
The complete nucleotide sequence of the tryptophan operon of Escherichia coli
1Department of Biological Sciences, Stanford University Stanford, CA 94305 2Department of Molecular Biophysics and Biochemistry, Yale University New Haven, CT 06510 3Department of Microbiology, University of Iowa Iowa City, IA 52242, USA
Received November 11, 1981. The tryptophan (trp) operon of Escherichia coli has become the basic reference structure for studies on tryptophan metabolism. Within the past five years the application of recombinant DNA and sequencing methodologies has permitted the characterization of the structural and functional elements in this gene cluster at the molecular level. In this summary report we present the complete nucleotide sequence for the five structural genes of the trp operon of E. coli together with the internal and flanking regions of regulatory information.
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