Skip Navigation

This Article
Right arrow Print PDF (3086K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Wong, Y.-C.
Right arrow Articles by Elgin, S. C.R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wong, Y.-C.
Right arrow Articles by Elgin, S. C.R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1981, Vol. 9, No. 24 6749-6762
© 1981

MOLECULAR BIOLOGY

DNase I hypersensitive sites of the chromatin for Drosophila melanogaster ribosomal protein 49 gene

Yuk-Chor Wong*, O'Connell Peter+, Michael Rosbash+ and Sarah C.R. Elgin*

*The Biological Laboratories, Harvard University Cambridge, MA 02138 +Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University Waltham, MA 02254, USA

Received October 16, 1981. By using an indirect end-labelling technique for mapping, five DNase I hypersensitive sites have been located in Drosophila melanogaster chromatin at the 5'-end of the gene coding for ribosomal protein 49. These sites typically span about 100-160 base pairs and are approximately the length of a nucleosome apart (center to center distance ca 245 bp). This is the first analysis of the chromatin structure of a constitutive house-keeping gene. The results support the hypothesis that the presence of such a DNase 1 hypersensitive site in chromatin is necessary for transcription in vivo. The presence of such sites may reflect some local changes in the conformation of the chromatin in the presumptive regulatory region.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
B. Y. Lu, P. C. R. Emtage, B. J. Duyf, A. J. Hilliker, and J. C. Eissenberg
Heterochromatin Protein 1 Is Required for the Normal Expression of Two Heterochromatin Genes in Drosophila
Genetics, June 1, 2000; 155(2): 699 - 708.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
L L Wallrath and S C Elgin
Position effect variegation in Drosophila is associated with an altered chromatin structure.
Genes & Dev., May 15, 1995; 9(10): 1263 - 1277.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F.-L. Sun, M. H. Cuaycong, C. A. Craig, L. L. Wallrath, J. Locke, and S. C. R. Elgin
The fourth chromosome of Drosophila melanogaster: Interspersed euchromatic and heterochromatic domains
PNAS, May 9, 2000; 97(10): 5340 - 5345.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.