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Nucleic Acids Research, 1981, Vol. 9, No. 24 6889-6906
© 1981

MOLECULAR BIOLOGY

Rifampidn inhibition of RNA synthesis by destabilisation of DNA-RNA polymerase-oligonucleotide-complexes

Wolfgang Schulz and Wolfram Zillig

Max-Planck-Institut filr Biochemie 8033 Martinsried bei Munchen, GFR

Received August 18, 1981. Although the antibiotic rifampicin inhibits the transcription of poly[d(A-T)] by E.coli RNA polymerase, a series of short oligonucleotides is produced. It is claimed that the overall inhibition of RNA synthesis by rifampicin is caused by a destabilising effect on the binding of the intermediate oligonucleotides to the active enzyme-DNA complex.

Rifampicin itself can only interact specifically with RNA polymerase if the enzyme is free or in a binary complex with DNA.

However, the enzyme is not susceptible in a ternary complex, even if the "RNA" is as short as a trinucleotide.


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