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Nucleic Acids Research, 1981, Vol. 9, No. 24 7041-7052
© 1981


CHEMISTRY

The molecular electrostatic potential and steric accessibility of poly (dI.dC). Comparison with poly (dG.dC)

Richard Lavery and Bernard Pullman

Institut de Biologie Physico-Chimique, Laboratoire de Chimie Théorique associé au C.N.R.S. 13, rue Pierre et Marie Curie, 75005 Paris, France

Received September 11, 1981. The influence of the amino group of guanine on the molecular electrostatic potential and the accessibility to reactive sites of B-DNA is investigated by comparing the two model double helices poly (dI.dC) and poly (dG.dC). The calculations clarify the "disruptive" role of the guanine amino group on nucleic acid-polypeptide interactions.


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