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Nucleic Acids Research, 1981, Vol. 9, No. 4 971-981
© 1981

MOLECULAR BIOLOGY

DNA sequence of the constant gene region of the mouse immunoglobulin kappa chain

Werner Altenburger, Peter S. Neumaier, Michael Steinmetz and Hans G. Zachau

Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München GFR

Received December 30, 1980. The constant (C; ref. 3) gene segment of the immunoglobulin kappa light chain and about 1 kb upstream as well as downstream of the segment have been sequenced. The sequences of the C gene segment itself and parts of the upstream region were determined both in liver and in myeloma T DNA clones derived from the same mouse inbred strain. The sequences were identical, i.e. no somatic mutations were detected. Two sites in the region not coding for protein are discussed as possible targets of aberrant variable (V) gene translocations. Doublet frequencies were calculated in the approx. 2500 bp of the C region sequence reported in this paper and in the approx. 3400 bp of two rearranged V gene regions.


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