Skip Navigation

This Article
Right arrow Print PDF (410K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (39)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Burton, D. R.
Right arrow Articles by Reimarsson, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Burton, D. R.
Right arrow Articles by Reimarsson, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1981, Vol. 9, No. 5 1219-1228
© 1981

CHEMISTRY

The interaction of polyamines with DNA: a 23Na NMR study

Dennis R. Burton*, Sture Forsén and Pétur Reimarsson+

Physical Chemistry 2, Chemical Centre, University of Lund P.O. Box 740, S-220 07 Lund, Sweden

Received January 15, 1981.

The interaction between a variety of polyamines, both naturally occurring and synthetic, and calf thymus DNA has been studied using 23Na NMR. The relaxation behaviour of 23Na reflects the extent of interaction of Na+ with DNA phosphate groups and therefore the extent of charge neutralisation of DNA phosphate groups (P) by polyamine amino and imino groups (N) in solutions of DNA, polyamine and Na+ The studies reveal that whereas spermine and spermidine are capable of expelling nearly all of the Na+ ions from DNA at N/P{small tilde}1, diamines such as putrescine and homologues of spermine and spermidine are capable of neutralising only roughly 50% of DNA phosphates. The results provide a challenge to current models of DNA-polyamine interactions.

* Present address: Department of Biochemistry, University of Oxford, South Parks Road, Oxford, England.

+ Present address: Institute of Occupational Safety and Health, Sidumala 15, 105 Reykjavik, Iceland.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
S. Lindemose, P. E. Nielsen, and N. E. Mollegaard
Polyamines preferentially interact with bent adenine tracts in double-stranded DNA
Nucleic Acids Res., March 23, 2005; 33(6): 1790 - 1803.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
H. Deng, V. A. Bloomfield, J. M. Benevides, and G. J. T. Jr
Structural basis of polyamine-DNA recognition: spermidine and spermine interactions with genomic B-DNAs of different GC content probed by Raman spectroscopy
Nucleic Acids Res., September 1, 2000; 28(17): 3379 - 3385.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.