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Nucleic Acids Research, 1981, Vol. 9, No. 9 2195-2206
© 1981

CHEMISTRY

Conformational stability of alternating d (CG) oligomers in high salt solution

Franco Quadrifoglio+, Giorgio Manzini+, Mark Vasser++, Kim Dinkelspiel++ and Roberto Crea++

+Istituto di Chimica, Laboratorio di Chimica delle Macromolecole, Università di Trieste Trieste, Italy ++Genentech, Inc. San Francisco, CA 94080, USA

Received February 25, 1981. The conformation of d(CG)n oligomers with n = 2,3 has been studied in aqueous solution in the presence of high salt concentration. A minimum n value of three is necessary to obtain a left-handed Z-helix. When d(CG)3 is flanked by three non Z-helicogenic alternating AT sequences the left-handed helix is unstable and a B-type conformation is obtained also at high salt concentration.


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