Nucleic Acids Research Advance Access published online on August 26, 2006
Nucleic Acids Research, doi:10.1093/nar/gkl557
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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RecQ helicases: lessons from model organisms
Frontiers in Genetics NCCR Program, University of Geneva 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland 1 Department of Molecular Biology, University of Aarhus C.F Möllers Allé, Building 130, DK-8000 Aarhus C, Denmark
*To whom correspondence should be addressed. Tel: +41 22 379 6127; Fax: +41 22 379 6868; Email: Jennifer.Cobb{at}molbio.unige.ch
Received March 31, 2006. Revised July 18, 2006. Accepted July 18, 2006.
RecQ DNA helicases function during DNA replication and are essential for the maintenance of genome stability. There is increasing evidence that spontaneous genomic instability occurs primarily during DNA replication, and that proteins involved in the S-phase checkpoint are a principal defence against such instability. Cells that lack functional RecQ helicases exhibit phenotypes consistent with an inability to fully resume replication fork progress after encountering DNA damage or fork arrest. In this review we will concentrate on the various functions of RecQ helicases during S phase in model organisms.
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