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Nucleic Acids Research Advance Access published online on November 15, 2006
Nucleic Acids Research, doi:10.1093/nar/gkl775
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

eSLDB: eukaryotic subcellular localization database

Andea Pierleoni, Pier Luigi Martelli, Piero Fariselli and Rita Casadio*

Biocomputing Group, University of Bologna via Irnerio 42, 40126 Bologna, Italy

*To whom correspondence should be addressed. Tel: +39 0512094005; Fax: +39 051242576; Email: casadio{at}alma.unibo.it

Received August 9, 2006. Revised September 27, 2006. Accepted September 29, 2006.

Eukaryotic Subcellular Localization DataBase collects the annotations of subcellular localization of eukaryotic proteomes. So far five proteomes have been processed and stored: Homo sapiens, Mus musculus, Caenorhabditis elegans, Saccharomyces cerevisiae and Arabidopsis thaliana. For each sequence, the database lists localization obtained adopting three different approaches: (i) experimentally determined (when available); (ii) homology-based (when possible); and (iii) predicted. The latter is computed with a suite of machine learning based methods, developed in house. All the data are available at our website and can be searched by sequence, by protein code and/or by protein description. Furthermore, a more complex search can be performed combining different search fields and keys. All the data contained in the database can be freely downloaded in flat file format. The database is available at http://gpcr.biocomp.unibo.it/esldb/.


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