Nucleic Acids Research Advance Access published online on October 25, 2006
Nucleic Acids Research, doi:10.1093/nar/gkl779
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Database Paper |
Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research
1 Beijing Institute of Genomics, Chinese Academy of Sciences, B-6 Airport Industrial Zone Beijing 101300, China 2 Institute of Computing Technology, Chinese Academy of Sciences Beijing 100080, China 3 James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou 310007 China 4 Joint Center for Microbial Genomics, Chinese Academy of Sciences Beijing 101300, China 5 Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences Beijing 100080, China
*To whom correspondence should be addressed. Tel: +86 10 80485492; Fax: +86 10 80498676; Email: wangjing{at}genomics.org.cn
Received August 12, 2006. Revised September 18, 2006. Accepted October 1, 2006.
Frequent outbreaks of highly pathogenic avian influenza and the increasing data available for comparative analysis require a central database specialized in influenza viruses (IVs). We have established the Influenza Virus Database (IVDB) to integrate information and create an analysis platform for genetic, genomic, and phylogenetic studies of the virus. IVDB hosts complete genome sequences of influenza A virus generated by Beijing Institute of Genomics (BIG) and curates all other published IV sequences after expert annotation. Our Q-Filter system classifies and ranks all nucleotide sequences into seven categories according to sequence content and integrity. IVDB provides a series of tools and viewers for comparative analysis of the viral genomes, genes, genetic polymorphisms and phylogenetic relationships. A search system has been developed for users to retrieve a combination of different data types by setting search options. To facilitate analysis of global viral transmission and evolution, the IV Sequence Distribution Tool (IVDT) has been developed to display the worldwide geographic distribution of chosen viral genotypes and to couple genomic data with epidemiological data. The BLAST, multiple sequence alignment and phylogenetic analysis tools were integrated for online data analysis. Furthermore, IVDB offers instant access to pre-computed alignments and polymorphisms of IV genes and proteins, and presents the results as SNP distribution plots and minor allele distributions. IVDB is publicly available at http://influenza.genomics.org.cn
*Correspondence may also be addressed to Jun Yu. Tel: +86 10 80481455; Fax: +86 10 80498676; Email: junyu{at}genomics.org.cn
The authors wish it to be known that, in their opinion, the first three authors should be regarded as First Authors.
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