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Nucleic Acids Research Advance Access published online on December 13, 2006
Nucleic Acids Research, doi:10.1093/nar/gkl848
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

D-HaploDB: a database of definitive haplotypes determined by genotyping complete hydatidiform mole samples

Koichiro Higasa, Katsuyuki Miyatake, Yoji Kukita, Tomoko Tahira and Kenshi Hayashi*

Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University Fukuoka, Fukuoka 812-8582, Japan

*To whom correspondence should be addressed. Tel: +81 92 642 6171; Fax: +81 92 632 2375; E-mail: khayashi{at}gen.kyushu-u.ac.jp

Received August 15, 2006. Revised October 8, 2006. Accepted October 9, 2006.

The Definitive Haplotype Database (D-HaploDB) is a web-accessible resource of genome-wide definitive haplotypes determined from a collection of Japanese complete hydatidiform moles (CHMs), each of which carries a genome derived from a single sperm. Currently, the database contains genotypes for 281 439 common SNPs from 74 CHMs which were determined by a high-throughput array-based oligonucleotide hybridization technique. The database also presents maps of haplotype blocks and linkage disequilibrium bins together with tagSNPs that might prove useful for association studies of disease genes. Cryptic relatedness among the samples in this study is unlikely, because the formation of a CHM is a maternal event of rare sporadic occurrence, and its genotype is that of the incoming sperm. This is demonstrated by the absence of long extended shared haplotypes (ESHs). The D-HaploDB is freely accessible via the Internet at http://orca.gen.kyushu-u.ac.jp

The authors wish it to be known that, in their opinion, the first three authors should be regarded as joint First Authors


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