Nucleic Acids Research Advance Access published online on November 27, 2006
Nucleic Acids Research, doi:10.1093/nar/gkl859
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Michigan Molecular Interactions (MiMI): putting the jigsaw puzzle together
Center for Computational Medicine and Biology,University of Michigan Ann Arbor, MI 48109, USA
*To whom correspondence should be addressed at Department of Electrical Engineering and Computer Science, University of Michigan, 2260 Hayward Avenue, Ann Arbor, MI 48109, USA. Tel: +1 734 763 4433; Fax: +1 734 763 8094; Email: apchapma{at}umich.edu
Received August 15, 2006. Revised September 13, 2006. Accepted October 1, 2006.
Protein interaction data exists in a number of repositories. Each repository has its own data format, molecule identifier and supplementary information. Michigan Molecular Interactions (MiMI) assists scientists searching through this overwhelming amount of protein interaction data. MiMI gathers data from well-known protein interaction databases and deep-merges the information. Utilizing an identity function, molecules that may have different identifiers but represent the same real-world object are merged. Thus, MiMI allows the users to retrieve information from many different databases at once, highlighting complementary and contradictory information. To help scientists judge the usefulness of a piece of data, MiMI tracks the provenance of all data. Finally, a simple yet powerful user interface aids users in their queries, and frees them from the onerous task of knowing the data format or learning a query language. MiMI allows scientists to query all data, whether corroborative or contradictory, and specify which sources to utilize. MiMI is part of the National Center for Integrative Biomedical Informatics (NCIBI) and is publicly available at: http://mimi.ncibi.org.
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.
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