Skip Navigation



Nucleic Acids Research Advance Access published online on November 3, 2006
Nucleic Acids Research, doi:10.1093/nar/gkl875
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (1862K) Freely available
Right arrow Screen PDF (605K) Freely available
Right arrowOA All Versions of this Article:
34/21/6126    most recent
gkl875v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Lopez-Garcia, J.
Right arrow Articles by Ali, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lopez-Garcia, J.
Right arrow Articles by Ali, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Molecular Biology

ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases

Jorge Lopez-Garcia, Manikandan Periyasamy, Ross S. Thomas, Mark Christian1, Maria Leao2, Parmjit Jat3, Karin B. Kindle4, David M. Heery4, Malcolm G. Parker1, Lakjaya Buluwela, Tahereh Kamalati and Simak Ali*

Department of Oncology, Imperial College London Du Cane Road, London W12 0NN, UK 1 Institute of Reproductive and Developmental Biology, Imperial College London Du Cane Road, London W12 0NN, UK 2 Ludwig Institute for Cancer Research, University College London Branch 91 Riding House Street, London W1W 7BS, UK 3 Department of Neurodegenerative Disease, Institute of Neurology, University College London Queen Square, London WC1N 3BG, UK 4 School of Pharmacy, University of Nottingham University Park, Nottingham NG7 2RD, UK

*To whom correspondence should be addressed. Tel: +44 20 8383 3789; Fax: +44 20 8383 5830; Email: simak.ali{at}imperial.ac.uk

Received August 4, 2006. Revised October 5, 2006. Accepted October 6, 2006.

The regulation of gene expression by estrogen receptor-{alpha} (ER{alpha}) requires the coordinated and temporal recruitment of diverse sets of transcriptional co-regulator complexes, which mediate nucleosome remodelling and histone modification. Using ER{alpha} as bait in a yeast two-hybrid screen, we have identified a novel ER{alpha}-interacting protein, ZNF366, which is a potent corepressor of ER{alpha} activity. The interaction between ZNF366 and ER{alpha} has been confirmed in vitro and in vivo, and is mediated by the zinc finger domains of the two proteins. Further, we show that ZNF366 acts as a corepressor by interacting with other known ER{alpha} corepressors, namely RIP140 and CtBP, to inhibit expression of estrogen-responsive genes in vivo. Together, our results indicate that ZNF366 may play an important role in regulating the expression of genes in response to estrogen.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. Palijan, I. Fernandes, Y. Bastien, L. Tang, M. Verway, M. Kourelis, L. E. Tavera-Mendoza, Z. Li, V. Bourdeau, S. Mader, et al.
Function of Histone Deacetylase 6 as a Cofactor of Nuclear Receptor Coregulator LCoR
J. Biol. Chem., October 30, 2009; 284(44): 30264 - 30274.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Malarstig, A. Buil, J. C. Souto, R. Clarke, F. Blanco-Vaca, J. Fontcuberta, J. Peden, M. Andersen, A. Silveira, S. Barlera, et al.
Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study
Blood, August 13, 2009; 114(7): 1417 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Ali, D. A. Heathcote, S. H.B. Kroll, A. S. Jogalekar, B. Scheiper, H. Patel, J. Brackow, A. Siwicka, M. J. Fuchter, M. Periyasamy, et al.
The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity
Cancer Res., August 1, 2009; 69(15): 6208 - 6215.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. B. Dammer and M. B. Sewer
Phosphorylation of CtBP1 by cAMP-dependent Protein Kinase Modulates Induction of CYP17 by Stimulating Partnering of CtBP1 and 2
J. Biol. Chem., March 14, 2008; 283(11): 6925 - 6934.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.