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Nucleic Acids Research Advance Access published online on December 1, 2006
Nucleic Acids Research, doi:10.1093/nar/gkl957
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

The GermOnline cross-species systems browser provides comprehensive information on genes and gene products relevant for sexual reproduction

Alexandre Gattiker, Christa Niederhauser-Wiederkehr, James Moore, Leandro Hermida and Michael Primig*

Biozentrum & Swiss Institute of Bioinformatics, Klingelbergstrasse 50-70 CH-4056 Basel, Switzerland

*To whom correspondence should be addressed. Tel: +41 61 267 2098; Fax: +41 61 267 3398; Email: michael.primig{at}unibas.ch

Received September 15, 2006. Revised October 24, 2006. Accepted October 24, 2006.

We report a novel release of the GermOnline knowledgebase covering genes relevant for the cell cycle, gametogenesis and fertility. GermOnline was extended into a cross-species systems browser including information on DNA sequence annotation, gene expression and the function of gene products. The database covers eight model organisms and Homo sapiens, for which complete genome annotation data are available. The database is now built around a sophisticated genome browser (Ensembl), our own microarray information management and annotation system (MIMAS) used to extensively describe experimental data obtained with high-density oligonucleotide microarrays (GeneChips) and a comprehensive system for online editing of database entries (MediaWiki). The RNA data include results from classical microarrays as well as tiling arrays that yield information on RNA expression levels, transcript start sites and lengths as well as exon composition. Members of the research community are solicited to help GermOnline curators keep database entries on genes and gene products complete and accurate. The database is accessible at http://www.germonline.org/.

Present address:

Leandro Hermida, Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland


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