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Nucleic Acids Research Advance Access published online on November 29, 2006
Nucleic Acids Research, doi:10.1093/nar/gkl969
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

Snap: an integrated SNP annotation platform

Shengting Li1,2, Lijia Ma2,3, Heng Li1,2, Søren Vang4, Yafeng Hu2, Lars Bolund1,2 and Jun Wang1,2,5,*

1 The Institute of Human Genetics, University of Aarhus DK-8000 Aarhus C. Denmark 2 Beijing Genomics Institute (BGI), Chinese Academy of Sciences (CAS) Beijing Airport Industrial Zone B-6, Beijing 101300, China 3 Graduate University of the Chinese Academy of Sciences, Yuquan Road 19A Beijing 100049, China 4 Research Unit for Molecular Medicine, Aarhus University Hospital and Faculty of Health Sciences DK-8200 Aarhus N, Denmark 5 College of Life Sciences, Peking University Beijing 100871, China

*To whom correspondence should be addressed. Tel: +86 10 80481552; Fax: +86 10 80498676; Email: wangj{at}genomics.org.cn

Received August 14, 2006. Revised October 11, 2006. Accepted October 13, 2006.

Snap (Single Nucleotide Polymorphism Annotation Platform) is a server designed to comprehensively analyze single genes and relationships between genes basing on SNPs in the human genome. The aim of the platform is to facilitate the study of SNP finding and analysis within the framework of medical research. Using a user-friendly web interface, genes can be searched by name, description, position, SNP ID or clone name. Several public databases are integrated, including gene information from Ensembl, protein features from Uniprot/SWISS-PROT, Pfam and DAS-CBS. Gene relationships are fetched from BIND, MINT, KEGG and are integrated with ortholog data from TreeFam to extend the current interaction networks. Integrated tools for primer-design and mis-splicing analysis have been developed to facilitate experimental analysis of individual genes with focus on their variation. Snap is available at http://snap.humgen.au.dk/ and at http://snap.genomics.org.cn/.

*Correspondence may also be addressed to Lars Bolund. Tel: +45 89421675; Fax: +45 86123173; Email: bolund{at}humgen.au.dk

The authors wish it to be known that, in their opinion, the first four authors should be regarded as joint First Authors


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