Nucleic Acids Research Advance Access published online on November 16, 2006
Nucleic Acids Research, doi:10.1093/nar/gkl970
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euHCVdb: the European hepatitis C virus database
Institut de Biologie et Chimie des Protéines (UMR5086), CNRS, University of Lyon 1, IFR 128 BioSciences Lyon-Gerland France 1 Swiss Institute of Bioinformatics, Geneva Switzerland 2 Department for Molecular Virology, University of Heidelberg Germany 3 Institute for Immunology, University of Munich Germany 4 Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne Switzerland 5 Department of Virology, INSERM U635, Henri Mondor Hospital, University of Paris XII Creteil, France 6 Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University New York, NY 7 INSERM U271, Lyon France
*To whom correspondence should be addressed. Tel: +33 4 37 65 29 47; Fax: +33 4 72 72 26 04; Email: c.combet{at}ibcp.fr
Received August 10, 2006. Accepted October 20, 2006.
The hepatitis C virus (HCV) genome shows remarkable sequence variability, leading to the classification of at least six major genotypes, numerous subtypes and a myriad of quasispecies within a given host. A database allowing researchers to investigate the genetic and structural variability of all available HCV sequences is an essential tool for studies on the molecular virology and pathogenesis of hepatitis C as well as drug design and vaccine development. We describe here the European Hepatitis C Virus Database (euHCVdb, http://euhcvdb.ibcp.fr), a collection of computer-annotated sequences based on reference genomes. The annotations include genome mapping of sequences, use of recommended nomenclature, subtyping as well as three-dimensional (3D) molecular models of proteins. A WWW interface has been developed to facilitate database searches and the export of data for sequence and structure analyses. As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses.
Members of the euHCVdb Scientific Board: Ralf Bartenschlager, Helmut Diepolder, Darius Moradpour, Jean-Michel Pawlotsky, Charles M. Rice, Christian Trépo and François Penin
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