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Nucleic Acids Research Advance Access published online on November 29, 2006
Nucleic Acids Research, doi:10.1093/nar/gkl978
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© 2006 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

MBGD: a platform for microbial comparative genomics based on the automated construction of orthologous groups

Ikuo Uchiyama

National Institute for Basic Biology, National Institutes of Natural Sciences Nishigonaka 38, Myodaiji, Okazaki 444-8585, Japan

Tel: +81 564 55 7629; Fax: +81 564 55 7625; Email: uchiyama{at}nibb.ac.jp

Received September 15, 2006. Revised October 26, 2006. Accepted October 26, 2006.

The microbial genome database for comparative analysis (MBGD) is a comprehensive platform for microbial comparative genomics. The central function of MBGD is to create orthologous groups among multiple genomes from precomputed all-against-all similarity relationships using the DomClust algorithm. The database now contains >300 published genomes and the number continues to grow. For researchers who are interested in ongoing genome projects, we have now started a new service called ‘My MBGD,’ which allows users to add their own genome sequences to MBGD for the purpose of identifying orthologs among both the new and the existing genomes. Furthermore, in order to make available the rapidly accumulating information on closely related genome sequences, we enhanced the interface for pairwise genome comparisons using the CGAT interface, which allows users to see nucleotide sequence alignments of non-coding as well as coding regions. MBGD is available at http://mbgd.genome.ad.jp/.


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