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Nucleic Acids Research Advance Access published online on May 8, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm279
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Multiple whole genome alignments and novel biomedical applications at the VISTA portal

Michael Brudno1, Alexander Poliakov2, Simon Minovitsky2, Igor Ratnere2 and Inna Dubchak2,3,*

1Department of Computer Science, Banting and Best Department of Medical Research, University of Toronto, 6 King's College Road, Toronto, ON, Canada M5S 3G4, 2Genomics Division, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 USA and 3US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA

*To whom correspondence should be addressed. Tel: +1-510-495-2419; Fax: +1-510-486-5614; Email: ildubchak{at}lbl.gov

Received February 1, 2007. Revised April 6, 2007. Accepted April 11, 2007.

The VISTA portal for comparative genomics is designed to give biomedical scientists a unified set of tools to lead them from the raw DNA sequences through the alignment and annotation to the visualization of the results. The VISTA portal also hosts the alignments of a number of genomes computed by our group, allowing users to study the regions of their interest without having to manually download the individual sequences. Here we describe various algorithmic and functional improvements implemented in the VISTA portal over the last 2 years. The VISTA Portal is accessible at http://genome.lbl.gov/vista.


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