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Nucleic Acids Research Advance Access published online on May 25, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm364
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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ProtSweep, 2Dsweep and DomainSweep: protein analysis suite at DKFZ

C. del Val1,2,*, P. Ernst1, M Falkenhahn1, C. Fladerer1, K. H. Glatting1, S Suhai1 and A. Hotz-Wagenblatt1

1DKFZ, German Cancer Research Center, Division of Molecular Biophysics, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany and 2Department of Computer Science and Artificial Intelligence, ETSII University of Granada, C/Daniel Saucedo Aranda s/n 18071, Granada, Spain

*To whom correspondence should be addressed. Tel: +49-6221-422349; Fax: +49-6221-439633; Email: c.delval{at}dkfz.de, delval{at}decsai.ugr.as

Received January 31, 2007. Revised April 4, 2007. Accepted April 25, 2007.

The wealth of transcript information that has been made publicly available in recent years has led to large pools of individual web sites offering access to bioinformatics software. However, finding out which services exist, what they can or cannot do, how to use them and how to feed results from one service to the next one in the right format can be very time and resource consuming, especially for non-experts.

Automating this task, we present a suite of protein annotation pipelines (tasks) developed at the German Cancer Research Centre (DKFZ) oriented to protein annotation by homology (ProtSweep), by domain analysis (DomainSweep), and by secondary structure elements (2Dsweep). The aim of these tasks is to perform an exhaustive structural and functional analysis employing a wide variety of methods in combination with the most updated public databases. The three servers are available for academic users at the HUSAR open server http://genius.embnet.dkfz-heidelberg.de/menu/biounit/open-husar/


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