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Nucleic Acids Research Advance Access published online on June 22, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm371
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry

Leonid Zamdborg, Richard D. LeDuc*, Kevin J. Glowacz, Yong-Bin Kim, Vinayak Viswanathan, Ian T. Spaulding, Bryan P. Early, Eric J. Bluhm, Shannee Babai and Neil L. Kelleher

Department of Chemistry, University of Illinois, Urbana, IL, 61801, USA

*To whom correspondence should be addressed. Tel: +1 217 244 7355; Fax: +1 217 244 8068; Email: rleduc{at}uiuc.edu

Received January 31, 2007. Revised April 4, 2007. Accepted April 26, 2007.

ProSight PTM 2.0 (http://prosightptm2.scs.uiuc.edu) is the next generation of the ProSight PTM web-based system for the identification and characterization of proteins using top down tandem mass spectrometry. It introduces an entirely new data-driven interface, integrated Sequence Gazer for protein characterization, support for fixed modifications, terminal modifications and improved support for multiple precursor ions (multiplexing). Furthermore, it supports data import and export for local analysis and collaboration.


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