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Nucleic Acids Research Advance Access published online on September 25, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm697
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

The Gypsy Database (GyDB) of mobile genetic elements

C. Lloréns1,2,*, R. Futami1, D. Bezemer3 and A. Moya2,4

1Biotech Vana, Valencia, 2Institut Cavanilles de Biodiversitat i Biología Evolutiva Universitat de València, Spain, 3HIV Monitoring Foundation, Amsterdam, The Netherlands and 4CIBER de Epidemiología y Salud Pública (CIBERESP), Spain

*To whom correspondence should be addressed. Tel: +34 963 553 182; Fax: +34 963 561 641; Email: carlos.llorens{at}uv.es

Received June 29, 2007. Revised August 19, 2007. Accepted August 22, 2007.

In this article, we introduce the Gypsy Database (GyDB) of mobile genetic elements, an in-progress database devoted to the non-redundant analysis and evolutionary-based classification of mobile genetic elements. In this first version, we contemplate eukaryotic Ty3/Gypsy and Retroviridae long terminal repeats (LTR) retroelements. Phylogenetic analyses based on the gag-pro-pol internal region commonly presented by these two groups strongly support a certain number of previously described Ty3/Gypsy lineages originally reported from reverse-transcriptase (RT) analyses. Vertebrate retroviruses (Retroviridae) are also constituted in several monophyletic groups consistent with genera proposed by the ICTV nomenclature, as well as with the current tendency to classify both endogenous and exogenous retroviruses by three major classes (I, II and III). Our inference indicates that all protein domains codified by the gag-pro-pol internal region of these two groups agree in a collective presentation of a particular evolutionary history, which may be used as a main criterion to differentiate their molecular diversity in a comprehensive collection of phylogenies and non-redundant molecular profiles useful in the identification of new Ty3/Gypsy and Retroviridae species. The GyDB project is available at http://gydb.uv.es.


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