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Nucleic Acids Research Advance Access first published online on October 2, 2007
This version published online on October 3, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm735
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Poly(ADP-ribosyl)ation in mammalian ageing

Sascha Beneke and Alexander Bürkle*

Molecular Toxicology Group, Department of Biology, University of Konstanz, D-78457 Konstanz, Germany

*To whom correspondence should be addressed. Tel: +49 7531 884035; Fax: +49 7531 884033; Email: alexander.buerkle{at}uni-konstanz.de

Received July 16, 2007. Revised August 31, 2007. Accepted September 4, 2007.

Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA damage-induced poly(ADP-ribosyl)ation and mammalian longevity. Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through which poly(ADP-ribosyl)ation might act as a factor that limits the rate of ageing.


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