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Nucleic Acids Research Advance Access published online on December 26, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm854
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

PepCyber:P~PEP: a database of human protein–protein interactions mediated by phosphoprotein-binding domains

Wuming Gong1, Dihan Zhou1, Yongliang Ren1, Yejun Wang1, Zhixiang Zuo1, Yanping Shen1, Feifei Xiao1, Qi Zhu2, Ailing Hong3, Xiaochuan Zhou4, Xiaolian Gao2 and Tongbin Li1,*

1Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, 2Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, 3Atactic Technologies and 4LC Sciences, Houston, TX 77054, USA

*To whom correspondence should be addressed. Tel: 612 626 3481; Fax: 612 626 3257; Email: toli{at}biocompute.umn.edu Correspondence may also be addressed to Xiaolian Gao. Tel: 713 743 2805; Fax: 713 743 2636; Email: xgao{at}uh.edu

Received August 16, 2007. Revised September 25, 2007. Accepted September 26, 2007.

Phosphoprotein-binding domains (PPBDs) mediate many important cellular and molecular processes. Ten PPBDs have been known to exist in the human proteome, namely, 14-3-3, BRCT, C2, FHA, MH2, PBD, PTB, SH2, WD-40 and WW. PepCyber:P~PEP is a newly constructed database specialized in documenting human PPBD-containing proteins and PPBD-mediated interactions. Our motivation is to provide the research community with a rich information source emphasizing the reported, experimentally validated data for specific PPBD–PPEP interactions. This information is not only useful for designing, comparing and validating the relevant experiments, but it also serves as a knowledge-base for computationally constructing systems signaling pathways and networks. PepCyber:P~PEP is accessible through the URL, http://www.pepcyber.org/PPEP/. The current release of the database contains 7044 PPBD-mediated interactions involving 337 PPBD-containing proteins and 1123 substrate proteins.

The authors wish it to be known that, in their opinion, the first three authors should be regarded as joint First Authors


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