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Nucleic Acids Research Advance Access published online on October 26, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm907
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

The Molecule Pages database

Brian Saunders1, Stephen Lyon1, Matthew Day2, Brenda Riley2, Emily Chenette3 and Shankar Subramaniam1,4,*

1San Diego Supercomputer Center San Diego, La Jolla, CA 92093, 2Nature Publishing Group, 25 First Street, Cambridge, MA 02141, USA, 3Nature Publishing Group, The Macmillan Building, 4 Crinan Street, London N1 9XW, UK and 4Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA

*To whom correspondence should be addressed. Tel: +1 858 822 0986; Fax: +1 858 822 3752; Email: shankar{at}sdsc.edu

Received August 31, 2007. Revised October 4, 2007. Accepted October 5, 2007.

The UCSD-Nature Signaling Gateway Molecule Pages (http://www.signaling-gateway.org/molecule) provides essential information on more than 3800 mammalian proteins involved in cellular signaling. The Molecule Pages contain expert-authored and peer-reviewed information based on the published literature, complemented by regularly updated information derived from public data source references and sequence analysis. The expert-authored data includes both a full-text review about the molecule, with citations, and highly structured data for bioinformatics interrogation, including information on protein interactions and states, transitions between states and protein function. The expert-authored pages are anonymously peer reviewed by the Nature Publishing Group. The Molecule Pages data is present in an object-relational database format and is freely accessible to the authors, the reviewers and the public from a web browser that serves as a presentation layer. The Molecule Pages are supported by several applications that along with the database and the interfaces form a multi-tier architecture. The Molecule Pages and the Signaling Gateway are routinely accessed by a very large research community.


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