Nucleic Acids Research Advance Access published online on October 26, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm936
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CORUM: the comprehensive resource of mammalian protein complexes
1Institute for Bioinformatics (MIPS), German Research Center for Environmental Health, Ingolstaedter Landstraße 1, D-85764 Neuherberg and 2Technische Universität München, Chair of Genome Oriented Bioinformatics, Center of Life and Food Science, D-85350 Freising-Weihenstephan, Germany
*To whom correspondence should be addressed. Tel: +49 89 3187 3189; Fax: 49 89 3187 3585; Email: andreas.ruepp{at}gsf.de
Received September 12, 2007. Revised October 10, 2007. Accepted October 11, 2007.
Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. The CORUM (http://mips.gsf.de/genre/proj/corum/index.html) database is a collection of experimentally verified mammalian protein complexes. Information is manually derived by critical reading of the scientific literature from expert annotators. Information about protein complexes includes protein complex names, subunits, literature references as well as the function of the complexes. For functional annotation, we use the FunCat catalogue that enables to organize the protein complex space into biologically meaningful subsets. The database contains more than 1750 protein complexes that are built from 2400 different genes, thus representing 12% of the protein-coding genes in human. A web-based system is available to query, view and download the data. CORUM provides a comprehensive dataset of protein complexes for discoveries in systems biology, analyses of protein networks and protein complex-associated diseases. Comparable to the MIPS reference dataset of protein complexes from yeast, CORUM intends to serve as a reference for mammalian protein complexes.
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