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Nucleic Acids Research Advance Access published online on November 14, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm977
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© 2007
The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

The 20 years of PROSITE

Nicolas Hulo1,*, Amos Bairoch1,2, Virginie Bulliard1, Lorenzo Cerutti3, Béatrice A. Cuche1, Edouard de Castro1, Corinne Lachaize1, Petra S. Langendijk-Genevaux1 and Christian J. A. Sigrist1

1Swiss Institute of Bioinformatics (SIB), Centre Medical Universitaire, 2Structural Biology and Bioinformatics Department, University of Geneva, 1 rue Michel Servet, CH-1211 Geneva 4 and 3Swiss Institute of Bioinformatics (SIB), Génopode, UNIL-Sorge, CH-1015 Lausanne, Switzerland

*To whom correspondence should be addressed: Tel: +4122 379 58 72; Fax: +4122 379 58 58; Email: Nicolas.Hulo{at}isb-sib.ch

Received September 14, 2007. Revised October 17, 2007. Accepted October 18, 2007.

PROSITE consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them. It is complemented by ProRule, a collection of rules based on profiles and patterns, which increases the discriminatory power of profiles and patterns by providing additional information about functionally and/or structurally critical amino acids. In this article, we describe the implementation of a new method to assign a status to pattern matches, the new PROSITE web page and a new approach to improve the specificity and sensitivity of PROSITE methods. The latest version of PROSITE (release 20.19 of 11 September 2007) contains 1319 patterns, 745 profiles and 764 ProRules. Over the past 2 years, about 200 domains have been added, and now 53% of UniProtKB/Swiss-Prot entries (release 54.2 of 11 September 2007) have a PROSITE match. PROSITE is available on the web at: http://www.expasy.org/prosite/.


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