Nucleic Acids Research Advance Access published online on December 23, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm995
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Database Issue |
The microRNA.org resource: targets and expression
1Computational and Systems Biology Center, Memorial Sloan-Kettering Cancer Center, NY and 2Department of Systems Biology, Harvard Medical School, Boston, MA, USA
*To whom correspondence should be addressed. Tel: +1 646 888 2626; Fax: +1 646 422 0717; Email: mirnatargets{at}cbio.mskcc.org
Received September 18, 2007. Revised October 19, 2007. Accepted October 22, 2007.
MicroRNA.org (http://www.microrna.org) is a comprehensive resource of microRNA target predictions and expression profiles. Target predictions are based on a development of the miRanda algorithm which incorporates current biological knowledge on target rules and on the use of an up-to-date compendium of mammalian microRNAs. MicroRNA expression profiles are derived from a comprehensive sequencing project of a large set of mammalian tissues and cell lines of normal and disease origin. Using an improved graphical interface, a user can explore (i) the set of genes that are potentially regulated by a particular microRNA, (ii) the implied cooperativity of multiple microRNAs on a particular mRNA and (iii) microRNA expression profiles in various tissues. To facilitate future updates and development, the microRNA.org database structure and software architecture is flexibly designed to incorporate new expression and target discoveries. The web resource provides users with functional information about the growing number of microRNAs and their interaction with target genes in many species and facilitates novel discoveries in microRNA gene regulation.
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