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Nucleic Acids Research Advance Access published online on December 23, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm995
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

The microRNA.org resource: targets and expression

Doron Betel1, Manda Wilson1, Aaron Gabow1, Debora S. Marks2 and Chris Sander1,*

1Computational and Systems Biology Center, Memorial Sloan-Kettering Cancer Center, NY and 2Department of Systems Biology, Harvard Medical School, Boston, MA, USA

*To whom correspondence should be addressed. Tel: +1 646 888 2626; Fax: +1 646 422 0717; Email: mirnatargets{at}cbio.mskcc.org

Received September 18, 2007. Revised October 19, 2007. Accepted October 22, 2007.

MicroRNA.org (http://www.microrna.org) is a comprehensive resource of microRNA target predictions and expression profiles. Target predictions are based on a development of the miRanda algorithm which incorporates current biological knowledge on target rules and on the use of an up-to-date compendium of mammalian microRNAs. MicroRNA expression profiles are derived from a comprehensive sequencing project of a large set of mammalian tissues and cell lines of normal and disease origin. Using an improved graphical interface, a user can explore (i) the set of genes that are potentially regulated by a particular microRNA, (ii) the implied cooperativity of multiple microRNAs on a particular mRNA and (iii) microRNA expression profiles in various tissues. To facilitate future updates and development, the microRNA.org database structure and software architecture is flexibly designed to incorporate new expression and target discoveries. The web resource provides users with functional information about the growing number of microRNAs and their interaction with target genes in many species and facilitates novel discoveries in microRNA gene regulation.


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