Nucleic Acids Research Advance Access published online on March 19, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn078
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Genomics |
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements
CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK
*To whom correspondence should be addressed. Tel: 0044 207 753 5969; Fax: 0044 207 753 5970; Email: stephen.neidle{at}pharmacy.ac.uk
Received January 24, 2008. Revised February 7, 2008. Accepted February 8, 2008.
We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes. By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding element GGGCGG, such that a large number of upstream PQSS incorporate the SP1-binding element.