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Nucleic Acids Research Advance Access published online on March 19, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn078
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Genomics

The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements

Alan K. Todd and Stephen Neidle*

CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK

*To whom correspondence should be addressed. Tel: 0044 207 753 5969; Fax: 0044 207 753 5970; Email: stephen.neidle{at}pharmacy.ac.uk

Received January 24, 2008. Revised February 7, 2008. Accepted February 8, 2008.

We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes. By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding element ‘GGGCGG’, such that a large number of upstream PQSS incorporate the SP1-binding element.


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