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Nucleic Acids Research Advance Access published online on January 19, 2009
Nucleic Acids Research, doi:10.1093/nar/gkn1080
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© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

RNA

Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR

Roberto Marcucci1, Maurizio Romano1,2, Fabian Feiguin1, Mary A. O'Connell3 and Francisco E. Baralle1,*

1International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012, 2Department of Physiology and Pathology, University of Trieste, Via A. Fleming 22, 34127, Trieste, Italy and 3MRC Human Genetics Unit Western General Hospital, Edinburgh EH4 2X U, UK

*To whom correspondence should be addressed. Tel: +39 040 3757337; Fax: +39 040 3757361; Email: baralle{at}icgeb.org

Received September 11, 2008. Revised December 19, 2008. Accepted December 23, 2008.

In Drosophila melanogaster, the expression of adenosine deaminase acting on RNA is regulated by transcription and alternative splicing so that at least four different isoforms are generated that have a tissue-specific splicing pattern. Even though dAdar has been extensively studied, the complete adult expression pattern has yet to be elucidated. In the present study, we investigate mature transcripts of dAdar arising from different promoters. Two predominant isoforms of dAdar are expressed in gonads and dAdar is transcribed from both the embryonic and the adult promoters. Furthermore, full-length transcripts containing the alternatively spliced exon-1 are expressed in a tissue-specific manner. The splicing factor B52/SRp55 binds within the alternative spliced exon 3a and plays a role in this alternative splicing event.


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