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Nucleic Acids Research Advance Access published online on May 6, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn239
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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ProfCom: a web tool for profiling the complex functionality of gene groups identified from high-throughput data

Alexey V. Antonov1, Thorsten Schmidt2,*, Yu Wang1 and Hans W. Mewes1,2

1Helmholtz Zentrum Munich, National Research Center for Environment and Health, Institute for Bioinformatics, Ingolstädter Landstraße 1, D-85764 Neuherberg and 2Department of Genome-Oriented Bioinformatics, Wissenschaftszentrum Weihenstephan, Technische Universität München, 85350 Freising, Germany

*To whom correspondence should be addressed. Tel: +49 8161 71 21 33; Fax: +49 8161 71 21 86; Email: t.schmidt{at}wzw.tum.de

Received February 1, 2008. Revised April 3, 2008. Accepted April 15, 2008.

ProfCom is a web-based tool for the functional interpretation of a gene list that was identified to be related by experiments. A trait which makes ProfCom a unique tool is an ability to profile enrichments of not only available Gene Ontology (GO) terms but also of ‘complex functions’. A ‘Complex function’ is constructed as Boolean combination of available GO terms. The complex functions inferred by ProfCom are more specific in comparison to single terms and describe more accurately the functional role of genes. ProfCom provides a user friendly dialog-driven web page submission available for several model organisms and supports most available gene identifiers. In addition, the web service interface allows the submission of any kind of annotation data. ProfCom is freely available at http://webclu.bio.wzw.tum.de/profcom/.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors


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