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Nucleic Acids Research Advance Access published online on April 29, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn241
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Web Server Issue

MassNet: a functional annotation service for protein mass spectrometry data

Daeui Park1, Byoung-Chul Kim1, Seong-Woong Cho1, Seong-Jin Park1, Jong-Soon Choi2, Seung Il Kim2, Jong Bhak1 and Sunghoon Lee1,*

1Korean BioInformation Center, KRIBB, Daejeon 305-806 and 2Proteomics Research Team, Korea Basic Science Institute, Daejeon 305-333, Korea

*To whom correspondence should be addressed. Tel: +82 42 879 8530; Fax: +82 42 879 8519; Email: ishoon{at}kribb.re.kr Correspondence may also be addressed to Jong Bhak. Tel: +82 42 879 8500; Fax: +82 42 879 8519; Email: jong{at}kribb.re.kr

Received February 23, 2008. Revised April 4, 2008. Accepted April 15, 2008.

Although mass spectrometry has been frequently used to identify proteins, there are no web servers that provide comprehensive functional annotation of those identified proteins. It is necessary to provide such web service due to a rapid increase in the data. We, therefore, introduce MassNet, which provides (i) physico-chemical analysis information, (ii) KEGG pathway assignment (iii) Gene Ontology mapping and (iv) protein–protein interaction (PPI) prediction for the data from MASCOT, Prospector and Profound. MassNet provides the prediction information for PPIs using both 3D structural interaction and experimental interaction deposited in PSIMAP, BIND, DIP, HPRD, IntAct, MINT, CYGD and BioGrid. The web service is freely available at http://massnet.kr or http://sequenceome.kobic.re.kr/MassNet/.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.


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