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Nucleic Acids Research Advance Access published online on October 1, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn617
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

NRED: a database of long noncoding RNA expression

Marcel E. Dinger1, Ken C. Pang1,2, Tim R. Mercer1, Mark L. Crowe1, Sean M. Grimmond1 and John S. Mattick1,*

1ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072 and 2T cell laboratory, Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences, Austin Hospital, Heidelberg, Victoria 3084 Australia

*To whom correspondence should be addressed. Tel: +61 7 3346 2079; Fax: +61 7 3346 2111; Email: j.mattick{at}imb.uq.edu.au

Received August 15, 2008. Accepted September 10, 2008.

In mammals, thousands of long non-protein-coding RNAs (ncRNAs) (>200 nt) have recently been described. However, the biological significance and function of the vast majority of these transcripts remain unclear. We have constructed a public repository, the Noncoding RNA Expression Database (NRED), which provides gene expression information for thousands of long ncRNAs in human and mouse. The database contains both microarray and in situ hybridization data, much of which is described here for the first time. NRED also supplies a rich tapestry of ancillary information for featured ncRNAs, including evolutionary conservation, secondary structure evidence, genomic context links and antisense relationships. The database is available at http://jsm-research.imb.uq.edu.au/NRED, and the web interface enables both advanced searches and data downloads. Taken together, NRED should significantly advance the study and understanding of long ncRNAs, and provides a timely and valuable resource to the scientific community.

The authors wish it to be known that, in their opinion, the first two authors should be regards as joint First Authors.


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