Nucleic Acids Research Advance Access published online on October 23, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn728
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IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels
1Centres for Cardiovascular Science and Neuroscience Research, The Queen's Medical Research Institute, 2Institute of Evolutionary Biology, Ashworth Labs, 3School of Informatics, University of Edinburgh, Edinburgh, UK, 4Laboratory of Genetics, National Institute of Mental Health, Bethesda, MD 20892-4405, USA, 5Department of Pharmacology, University of Washington, Seattle, WA 98195, USA, 6Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 2QQ, UK, 7Institut de Recherches Servier, 92150 Suresnes, France, 8Management Division, GlaxoSmithKline, Harlow, CM19 5AW, UK, 9GlaxoSmithKline Research and Development, Stevenage, Hertfordshire, UK, 10Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697, USA, 11Molecular Zoology Group, Institut de Génomique Fonctionelle de Lyon, Lyon, France, 12Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA, 13Venuvics Pharmaceuticals, Glenmoore, PA, USA 14Department of Molecular & Medical Pharmacology, University of California, Los Angeles, CA 90095-1735, USA, 15Neurosciences Institute, The University of Dundee, Dundee, DD1 9SY, UK, 16Centre National de la Recherche Scientifique, Montpellier, France, 17Wyeth Research, Collegeville, PA 19426, 18GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406, USA and 19HGNC, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK
*To whom correspondence should be addressed. Tel: +44 131 242 6693; Fax: +44 131 242 6779; Email: tony.harmar{at}ed.ac.uk, tharmar{at}mac.com
Received August 11, 2008. Revised September 30, 2008. Accepted October 1, 2008.
The IUPHAR database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated-like ion channel subunits encoded by the human, rat and mouse genomes. These genes represent the targets of approximately one-third of currently approved drugs and are a major focus of drug discovery and development programs in the pharmaceutical industry. IUPHAR-DB provides a comprehensive description of the genes and their functions, with information on protein structure and interactions, ligands, expression patterns, signaling mechanisms, functional assays and biologically important receptor variants (e.g. single nucleotide polymorphisms and splice variants). In addition, the phenotypes resulting from altered gene expression (e.g. in genetically altered animals or in human genetic disorders) are described. The content of the database is peer reviewed by members of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR); the data are provided through manual curation of the primary literature by a network of over 60 subcommittees of NC-IUPHAR. Links to other bioinformatics resources, such as NCBI, Uniprot, HGNC and the rat and mouse genome databases are provided. IUPHAR-DB is freely available at http://www.iuphar-db.org.
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