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Nucleic Acids Research Advance Access published online on November 7, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn732
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

INTERFEROME: the database of interferon regulated genes

Shamith A. Samarajiwa1,2, Sam Forster1, Katie Auchettl1 and Paul J. Hertzog1,2,*

1Center for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, and 2CRC for chronic inflammatory disease, North Melbourne, Victoria, Australia

*To whom correspondence should be addressed: Tel: +61 3 9594 7236; Fax: +61 3 9594 7211; Email: paul.hertzog{at}med.monash.edu.au

Correspondence may also be addressed to Shamith Samarajiwa. Email: shamith.samarajiwa{at}cancer.org.uk

Received August 15, 2008. Revised September 30, 2008. Accepted October 1, 2008.

INTERFEROME is an open access database of types I, II and III Interferon regulated genes (http://www.interferome.org) collected from analysing expression data sets of cells treated with IFNs. This database of interferon regulated genes integrates information from high-throughput experiments with annotation, ontology, orthologue sequences from 37 species, tissue expression patterns and gene regulatory information to enable a detailed investigation of the molecular mechanisms underlying IFN biology. INTERFEROME fulfils a need in infection, immunity, development and cancer research by providing computational tools to assist in identifying interferon signatures in gene lists generated by high-throughput expression technologies, and their potential molecular and biological consequences.


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