Skip Navigation



Nucleic Acids Research Advance Access published online on October 21, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn734
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (4937K) Freely available
Right arrow Screen PDF (1072K) Freely available
Right arrow Supplementary Data
Right arrowOA All Versions of this Article:
37/suppl_1/D216    most recent
gkn734v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Klimke, W.
Right arrow Articles by Tatusova, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klimke, W.
Right arrow Articles by Tatusova, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

The National Center for Biotechnology Information's Protein Clusters Database

William Klimke*, Richa Agarwala, Azat Badretdin, Slava Chetvernin, Stacy Ciufo, Boris Fedorov, Boris Kiryutin, Kathleen O’Neill, Wolfgang Resch, Sergei Resenchuk, Susan Schafer, Igor Tolstoy and Tatiana Tatusova

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA

*To whom correspondence should be addressed. Tel: +1 301 496 4859; Fax: +1 301 402 9651; Email: klimke{at}ncbi.nlm.nih.gov

Received August 21, 2008. Revised September 24, 2008. Accepted October 1, 2008.

Rapid increases in DNA sequencing capabilities have led to a vast increase in the data generated from prokaryotic genomic studies, which has been a boon to scientists studying micro-organism evolution and to those who wish to understand the biological underpinnings of microbial systems. The NCBI Protein Clusters Database (ProtClustDB) has been created to efficiently maintain and keep the deluge of data up to date. ProtClustDB contains both curated and uncurated clusters of proteins grouped by sequence similarity. The May 2008 release contains a total of 285 386 clusters derived from over 1.7 million proteins encoded by 3806 nt sequences from the RefSeq collection of complete chromosomes and plasmids from four major groups: prokaryotes, bacteriophages and the mitochondrial and chloroplast organelles. There are 7180 clusters containing 376 513 proteins with curated gene and protein functional annotation. PubMed identifiers and external cross references are collected for all clusters and provide additional information resources. A suite of web tools is available to explore more detailed information, such as multiple alignments, phylogenetic trees and genomic neighborhoods. ProtClustDB provides an efficient method to aggregate gene and protein annotation for researchers and is available at http://www.ncbi.nlm.nih.gov/sites/entrez?db=proteinclusters.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 DatabaseHome page
D. Vallenet, S. Engelen, D. Mornico, S. Cruveiller, L. Fleury, A. Lajus, Z. Rouy, D. Roche, G. Salvignol, C. Scarpelli, et al.
MicroScope: a platform for microbial genome annotation and comparative genomics
Database, November 25, 2009; 2009(0): bap021 - bap021.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
T. Davidsen, E. Beck, A. Ganapathy, R. Montgomery, N. Zafar, Q. Yang, R. Madupu, P. Goetz, K. Galinsky, O. White, et al.
The comprehensive microbial resource
Nucleic Acids Res., November 5, 2009; (2009) gkp912v1.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.