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Nucleic Acids Research Advance Access published online on October 18, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn750
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

The SWISS-MODEL Repository and associated resources

Florian Kiefer1,2, Konstantin Arnold1,2, Michael Künzli1,2, Lorenza Bordoli1,2 and Torsten Schwede1,2,*

1Biozentrum, University of Basel and 2SIB Swiss Institute of Bioinformatics, Basel, Switzerland

*To whom correspondence should be addressed. Tel: +41 61 267 15 81; Fax: +41 61 267 15 84; Email: torsten.schwede{at}unibas.ch

Received September 15, 2008. Accepted October 5, 2008.

SWISS-MODEL Repository (http://swissmodel.expasy.org/repository/) is a database of 3D protein structure models generated by the SWISS-MODEL homology-modelling pipeline. The aim of the SWISS-MODEL Repository is to provide access to an up-to-date collection of annotated 3D protein models generated by automated homology modelling for all sequences in Swiss-Prot and for relevant models organisms. Regular updates ensure that target coverage is complete, that models are built using the most recent sequence and template structure databases, and that improvements in the underlying modelling pipeline are fully utilised. As of September 2008, the database contains 3.4 million entries for 2.7 million different protein sequences from the UniProt database. SWISS-MODEL Repository allows the users to assess the quality of the models in the database, search for alternative template structures, and to build models interactively via SWISS-MODEL Workspace (http://swissmodel.expasy.org/workspace/). Annotation of models with functional information and cross-linking with other databases such as the Protein Model Portal (http://www.proteinmodelportal.org) of the PSI Structural Genomics Knowledge Base facilitates the navigation between protein sequence and structure resources.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.


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