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Nucleic Acids Research Advance Access published online on October 28, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn768
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Published by Oxford University Press 2008
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

Selectome: a database of positive selection

Estelle Proux1,2, Romain A. Studer1,2, Sébastien Moretti1,2 and Marc Robinson-Rechavi1,2,*

1Department of Ecology and Evolution, Biophore, Lausanne University and 2Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland

*To whom correspondence should be addressed: Tel: +41 21 692 42 20; Fax: +41 21 692 41 65; Email: marc.robinson-rechavi{at}unil.ch

Received August 12, 2008. Revised September 18, 2008. Accepted October 7, 2008.

Genome wide scans have shown that positive selection is relatively frequent at the molecular level. It is of special interest to identify which protein sites and which phylogenetic branches are affected. We present Selectome, a database which provides the results of a rigorous branch-site specific likelihood test for positive selection. The Web interface presents test results mapped both onto phylogenetic trees and onto protein alignments. It allows rapid access to results by keyword, gene name, or taxonomy based queries. Selectome is freely available at http://bioinfo.unil.ch/selectome/.

The authors wish it to be known that, in their opinion, the first three author should be regarded as joint First Authors.


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