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Nucleic Acids Research Advance Access published online on October 23, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn788
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

FlyBase: enhancing Drosophila Gene Ontology annotations

Susan Tweedie1,*, Michael Ashburner1, Kathleen Falls2, Paul Leyland1, Peter McQuilton1, Steven Marygold1, Gillian Millburn1, David Osumi-Sutherland1, Andrew Schroeder2, Ruth Seal1, Haiyan Zhang2 and The FlyBase Consortium{dagger}

1Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK and 2The Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA

*To whom correspondence should be addressed. Tel: +44 1223 333 963; Fax: +44 1223 333 992; Email: s.tweedie{at}gen.cam.ac.uk

Received September 19, 2008. Revised October 8, 2008. Accepted October 9, 2008.

FlyBase (http://flybase.org) is a database of Drosophila genetic and genomic information. Gene Ontology (GO) terms are used to describe three attributes of wild-type gene products: their molecular function, the biological processes in which they play a role, and their subcellular location. This article describes recent changes to the FlyBase GO annotation strategy that are improving the quality of the GO annotation data. Many of these changes stem from our participation in the GO Reference Genome Annotation Project—a multi-database collaboration producing comprehensive GO annotation sets for 12 diverse species.

Present address: Ruth Seal, EBI, Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK

{dagger}The FlyBase Consortium comprises: FlyBase-Harvard: W. Gelbart, L. Bitsoi, M. Crosby, A. Dirkmaat, D. Emmert, L. S. Gramates, K. Falls, R. Kulathinal, B. Matthews, M. Roark, S. Russo, A. Schroeder, S. St Pierre, H. Zhang, P. Zhou and M. Zytkovicz; FlyBase-Cambridge: M. Ashburner, N. Brown, P. Leyland, P. McQuilton, S. Marygold, G. Millburn, D. Osumi-Sutherland, R. Stefancsik, S. Tweedie and M. Williams; and FlyBase-Indiana: T. Kaufman, K. Matthews, J. Goodman, G. Grumbling, V. Strelets and R. Wilson.


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