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Nucleic Acids Research Advance Access published online on May 6, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp313
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© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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GeneSet2miRNA: finding the signature of cooperative miRNA activities in the gene lists

Alexey V. Antonov1,*, Sabine Dietmann1, Philip Wong1, Dominik Lutter1 and Hans W. Mewes1,2

1Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Institute for Bioinformatics and Systems Biology, Ingolstädter Landstraße 1, D-85764 Neuherberg and 2Department of Genome-Oriented Bioinformatics, Wissenschaftszentrum Weihenstephan, Technische Universität München, 85350 Freising, Germany

*To whom correspondence should be addressed. Tel: +49 89 3187 2788; Fax: +49 89 3187 3585; Email: a.antonov{at}helmholtz-muenchen.de

Received January 30, 2009. Revised April 17, 2009. Accepted April 18, 2009.

GeneSet2miRNA is the first web-based tool which is able to identify whether or not a gene list has a signature of miRNA-regulatory activity. As input, GeneSet2miRNA accepts a list of genes. As output, a list of miRNA-regulatory models is provided. A miRNA-regulatory model is a group of miRNAs (single, pair, triplet or quadruplet) that is predicted to regulate a significant subset of genes from the submitted list. GeneSet2miRNA provides a user friendly dialog-driven web page submission available for several model organisms. GeneSet2miRNA is freely available at http://mips.helmholtz-muenchen.de/proj/gene2mir/.


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