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Nucleic Acids Research Advance Access published online on May 8, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp321
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© 2009
The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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ATIVS: analytical tool for influenza virus surveillance

Yu-Chieh Liao1, Chin-Yu Ko1, Ming-Hsin Tsai1, Min-Shi Lee2,* and Chao A. Hsiung1,*

1Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences and 2Vaccine R&D Center, National Health Research Institutes, Zhunan 350, Miaoli County, Taiwan

*To whom correspondence should be addressed. Tel: +886 37 246 166. Ext. 36100; Fax: +886 37 586 467; Email: hsiung{at}nhri.org.tw

Correspondence may also be addressed to Min-Shi Lee. Tel: +886 37 246 166. Ext. 37742; Fax: +886 37 583 009; Email: minshi.lee{at}hotmail.com

Received January 30, 2009. Revised April 9, 2009. Accepted April 20, 2009.

The WHO Global Influenza Surveillance Network has routinely performed genetic and antigenic analyses of human influenza viruses to monitor influenza activity. Although these analyses provide supporting data for the selection of vaccine strains, it seems desirable to have user-friendly tools to visualize the antigenic evolution of influenza viruses for the purpose of surveillance. To meet this need, we have developed a web server, ATIVS (Analytical Tool for Influenza Virus Surveillance), for analyzing serological data of all influenza viruses and hemagglutinin sequence data of human influenza A/H3N2 viruses so as to generate antigenic maps for influenza surveillance and vaccine strain selection. Functionalities are described and examples are provided to illustrate its usefulness and performance. The ATIVS web server is available at http://influenza.nhri.org.tw/ATIVS/.


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