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Nucleic Acids Research Advance Access published online on June 5, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp438
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© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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DASMIweb: online integration, analysis and assessment of distributed protein interaction data

Hagen Blankenburg*, Fidel Ramírez, Joachim Büch and Mario Albrecht

Max Planck Institute for Informatics, Campus E1.4, 66123 Saarbrücken, Germany

*To whom correspondence should be addressed. Tel: +49 681 9325 328; Fax: +49 681 9325 399; Email: hagen.blankenburg{at}mpi-inf.mpg.de

Received February 28, 2009. Revised April 25, 2009. Accepted May 11, 2009.

In recent years, we have witnessed a substantial increase of the amount of available protein interaction data. However, most data are currently not readily accessible to the biologist at a single site, but scattered over multiple online repositories. Therefore, we have developed the DASMIweb server that affords the integration, analysis and qualitative assessment of distributed sources of interaction data in a dynamic fashion. Since DASMIweb allows for querying many different resources of protein and domain interactions simultaneously, it serves as an important starting point for interactome studies and assists the user in finding publicly accessible interaction data with minimal effort. The pool of queried resources is fully configurable and supports the inclusion of own interaction data or confidence scores. In particular, DASMIweb integrates confidence measures like functional similarity scores to assess individual interactions. The retrieved results can be exported in different file formats like MITAB or SIF. DASMIweb is freely available at http://www.dasmiweb.de.


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