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Nucleic Acids Research Advance Access published online on July 3, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp557
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© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Genome Integrity, Repair and Replication

Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance

Jacques Oberto1, Norman Breuil1, Arnaud Hecker1, Francesca Farina1, Céline Brochier-Armanet2,3, Emmanuel Culetto1,* and Patrick Forterre1,4,*

1Université Paris-Sud 11, CNRS, UMR8621, Institut de Génétique et Microbiologie, 91405 Orsay, 2Institut de Microbiologie de la Méditerranée (IFR88), Laboratoire de Chimie Bactérienne, UPR9043-CNRS, 13402 Marseille Cedex 20, 3Université de Provence – Aix-Marseille I, 13331 Marseille Cedex 3 and 4Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, 25 rue du Dr Roux, 75724 Paris Cedex 15, France

*To whom correspondence should be addressed. Tel: +33 1 69 15 74 89; Fax: +33 1 69 15 78 08; Email: patrick.forterre{at}igmors.u-psud.fr Correspondence may also be addressed to Emmanuel Culetto. Tel: +33 1 69 82 43 81; Fax: +33 1 69 82 43 86; Email: emmanuel.culetto{at}u-psud.fr

Received February 26, 2009. Revised June 15, 2009. Accepted June 15, 2009.

Yeast Qri7 and human OSGEPL are members of the orthologous Kae1(OSGEP)/YgjD protein family, the last class of universally conserved proteins without assigned function. Phylogenetic analyses indicate that the eukaryotic Qri7(OSGEPL) proteins originated from bacterial YgjD proteins. We have recently shown that the archaeal Kae1 protein is a DNA-binding protein that exhibits apurinic endonuclease activity in vitro. We show here that the Qri7/OSGEPL proteins localize in mitochondria and are involved in mitochondrial genome maintenance in two model eukaryotic organisms, Saccharomyces cerevisiae and Caenorhabditis elegans. Furthermore, S. cerevisiae Qri7 complements the loss of the bacterial YgjD protein in Escherichia coli, suggesting that Qri7/OSGEPL and YgjD proteins have retained similar functions in modern organisms. We suggest to name members of the Kae1(OSGEP)/YgjD family UGMP, for Universal Genome Maintenance Proteins.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.


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