Cover: In contrast to the sequence conservation of many repressors and activators, an unusually conserved thymine (red T) in the middle of bacteriophage P1 RepA protein binding sites suggests that DNA distortion or base flipping is a step of DNA replication. For further details see the paper by Schneider in this issue [Nucleic Acids Res. (2001) 29, 4881-4891].
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