Cover. Crystal structure of the actinomycin D-ATGCTGCAT complex. The figure on the left (ActD in skeletal and DNA in space-filling view) shows two ActDs, ActD1 (purple) and ActD2 (light blue), bound to DNA by intercalating its phenoxazone at the two GpC sites, separated by a T:T mispair. The figure on the right shows the back view of the same structure (ActD in space-filling and DNA in skeletal view). For further details see Hou et al. in this issue [Nucleic Acids Res. (2002) 30, 4910--4917].
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